Corbet E F, Tam J O, Zee K Y, Wong M C, Lo E C, Mombelli A W, Lang N P
University of Hong Kong, Faculty of Dentistry, Hong Kong.
Oral Dis. 1997 Mar;3(1):9-18. doi: 10.1111/j.1601-0825.1997.tb00003.x.
The aim of the present study was to test the presumptive therapeutic effect of chlorhexidine digluconate in a population with untreated gingivitis and presence of abundant calculus. SETTING AND STUDY DESIGN: Sixty subjects (approximately mean age of 23.4) were recruited from a knitting factory in the Province of Guangdong, People's Republic of China. By applying a double-blind clinical trial design the participants were divided into two groups (Test and Control) and matched according to their mean GI scores. The Test group (n = 20) was assigned to two daily mouthrinses for 6 days per week using 0.12% chlorhexidine digluconate (Peridex). The Control group (n = 40) rinsed twice daily with a placebo solution. All the rinsings were supervised and timed for 45 s. No attempt was made to influence the oral hygiene habits of the participants. Prior to and after 3 months of the supervised rinsing, plaque was scored using the Plaque Index system (PII), and gingivitis was assessed using the criteria of the Gingival Index system (GI). Calculus was scored according to the Calculus Surface Severity Index system (CSSI), and stain was also graded by the Discoloration Index system (DI).
After 3 months, the Test group (n = 13) showed significant reduction in mean PII, GI and percentage of gingival bleeding (GB%), while significant increases in mean DI were observed. The improvement in gingival health was observed at all regions with marked reduction in mean GI (from GI = 1.40 to 1.08) and GB% reduction by 24-52%. The proportion of GI = 2 was also reduced significantly from 50-36%. The Control group (n = 23) also showed a decrease in mean PII but significant increases in the mean GI and GB%. Intergroup comparison showed statistically significant differences between mean GI, percentage of gingival bleeding (GB%) and mean DI for the test and control groups after 3 months of supervised rinsing. However, there were no significant intergroup differences for mean PII.
In conclusion, there was a significant effect of chlorhexidine on gingivitis, although the effect may be too limited to assure prognostic benefits in the prevention of future disease progression.
本研究旨在测试葡萄糖酸氯己定对未经治疗的牙龈炎且牙结石丰富人群的假定治疗效果。
从中华人民共和国广东省的一家针织厂招募了60名受试者（平均年龄约23.4岁）。采用双盲临床试验设计，将参与者分为两组（试验组和对照组），并根据他们的平均牙龈指数（GI）得分进行匹配。试验组（n = 20）每周6天每天使用0.12%葡萄糖酸氯己定（派丽奥）进行两次漱口水含漱。对照组（n = 40）每天用安慰剂溶液漱口两次。所有含漱均受到监督，时间为45秒。未试图影响参与者的口腔卫生习惯。在监督含漱3个月之前和之后，使用菌斑指数系统（PII）对菌斑进行评分，并使用牙龈指数系统（GI）的标准评估牙龈炎。根据牙结石表面严重程度指数系统（CSSI）对牙结石进行评分，并且还通过变色指数系统（DI）对牙渍进行分级。
3个月后，试验组（n = 13）的平均PII、GI和牙龈出血百分比（GB%）显著降低，而平均DI显著增加。在所有区域均观察到牙龈健康状况有所改善，平均GI显著降低（从GI = 1.40降至1.08），GB%降低了24 - 52%。GI = 2的比例也从50%显著降至36%。对照组（n = 23）的平均PII也有所下降，但平均GI和GB%显著增加。组间比较显示，在监督含漱3个月后，试验组和对照组的平均GI、牙龈出血百分比（GB%）和平均DI之间存在统计学显著差异。然而，平均PII在组间没有显著差异。
总之，氯己定对牙龈炎有显著效果，尽管这种效果可能过于有限，无法确保在预防未来疾病进展方面具有预后益处。
