前列腺素D2抑制人类恶性肿瘤细胞的增殖。

Prostaglandin D2 inhibits the proliferation of human malignant tumor cells.

作者信息

Sakai T, Yamaguchi N, Shiroko Y, Sekiguchi M, Fujii G, Nishino H

出版信息

Prostaglandins. 1984 Jan;27(1):17-26. doi: 10.1016/0090-6980(84)90217-x.

Abstract

The cytotoxic effect of prostaglandin (PG) D2, PGE1 and PGF2 alpha was examined on human osteosarcoma cells (KSu cell line) in vitro, and PGD2 was most effective. DNA, RNA and protein syntheses of KSu cells were also found to be inhibited by PGD2 at a concentration of 5 micrograms/ml. Furthermore, the proliferation of various human malignant tumor cells was inhibited by PGD2 without exception so far. These results suggest that PGD2 shows an anti-neoplastic effect on a variety of human malignant tumor cells.

摘要

在体外研究了前列腺素（PG）D2、PGE1和PGF2α对人骨肉瘤细胞（KSu细胞系）的细胞毒性作用，发现PGD2的效果最为显著。还发现，浓度为5微克/毫升的PGD2可抑制KSu细胞的DNA、RNA和蛋白质合成。此外，到目前为止，PGD2无一例外地抑制了各种人类恶性肿瘤细胞的增殖。这些结果表明，PGD2对多种人类恶性肿瘤细胞具有抗肿瘤作用。