Schoenberg J B, Stemhagen A, Mogielnicki A P, Altman R, Abe T, Mason T J
J Natl Cancer Inst. 1984 May;72(5):973-81.
The occupational bladder cancer risk for New Jersey white males was estimated with the use of both industry-job title-based and exposure-based analyses of data from 658 incident cases and 1,258 general population controls. The overall bladder cancer risk attributable to occupational exposures was estimated as 20-22%. A wide variety of employment categories and exposures contributed to this risk. Odds ratios were significantly high for employment as garage and gas station workers and food counter workers and/or cooks and for exposure to leather, rubber, paint, printing ink, and other organic compounds. Odds ratios for textile mill workers, chemical workers, and metal workers for the a priori high-risk employment category and odds ratios for those exposed to dyes, chlorinated compounds, and rubber showed significant differences between younger and older subjects. Bladder cancer risk associated with occupational exposures was not limited to persons with initial exposures before 25 years of age. However, there was significantly decreasing risk for bladder cancer with increasing age at first exposure for chemical workers and metal workers and for the a priori high-risk materials and metals. Drivers and/or deliverymen and miscellaneous laborers had significantly increasing bladder cancer risk with increasing duration of employment.
利用基于行业职称和暴露情况的分析方法，对来自658例膀胱癌发病病例和1258名普通人群对照的数据进行分析，估算了新泽西州白人男性患职业性膀胱癌的风险。职业暴露导致的总体膀胱癌风险估计为20%-22%。多种就业类别和暴露因素导致了这种风险。车库和加油站工人、食品柜台工作人员和/或厨师的职业以及接触皮革、橡胶、油漆、印刷油墨和其他有机化合物的人群，其优势比显著较高。纺织厂工人、化学工人和金属工人在预先设定的高风险就业类别中的优势比，以及接触染料、氯化化合物和橡胶人群的优势比，在年轻和年长受试者之间存在显著差异。与职业暴露相关的膀胱癌风险并不局限于25岁之前首次接触的人群。然而，对于化学工人和金属工人以及预先设定的高风险材料和金属，随着首次接触年龄的增加，患膀胱癌的风险显著降低。司机和/或送货员以及杂工随着就业时间的增加，患膀胱癌的风险显著增加。
