膀胱癌风险：一项基于行业和职业的病例对照分析。
Risk of urinary bladder cancer: a case-control analysis of industry and occupation.
机构信息
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
BMC Cancer. 2009 Dec 15;9:443. doi: 10.1186/1471-2407-9-443.
BACKGROUND
Uncertainty remains about urinary bladder cancer (UBC) risk for many occupations. Here, we investigate the association between occupation, industry and UBC.
METHODS
Lifetime occupational history was collected by in-person interview for 604 newly diagnosed UBC patients and 604 cancer-free controls. Each job title was assigned a two-digit industry code and a three-digit occupation code. Odds ratios (ORs) for UBC associated with ever being employed in an industry or occupation were calculated by unconditional logistic regression adjusting for age, gender and smoking status. We also examined UBC risk by duration of employment (>0 to <10, >or=10 years) in industry or occupation.
RESULTS
Significantly increased risk of UBC was observed among waiters and bartenders (OR 2.87; 95% CI 1.05 to 7.72) and occupations related to medicine and health (OR 2.17; 95% CI 1.21 to 3.92), agricultural production, livestock and animal specialties (OR 1.90; 95% CI 1.03 to 3.49), electrical assembly, installation and repair (OR 1.69; 95% CI 1.07 to 2.65), communications (OR 1.74; 95% CI 1.00 to 3.01), and health services (OR 1.58; 95% CI 1.02 to 2.44). For these occupations we also observed a significant excess risk of UBC for long-term work (i.e. >or=10 years), with the exception of waiters and bartenders. Employment for 10 years or more was associated with increased risk of UBC in general farmers (OR 9.58; 95% CI 2.18 to 42.05), agricultural production of crops (OR 3.36; 95% CI 1.10 to 10.27), occupations related to bench working (OR 4.76; 95% CI 1.74 to 13.01), agricultural, fishery, forestry & related (OR 4.58; 95% CI 1.97 to 10.65), transportation equipment (OR 2.68; 95% CI 1.03 to 6.97), and structural work (OR 1.85; 95% CI 1.16 to 2.95).
CONCLUSIONS
This study provides evidence of increased risk of UBC for occupations that were previously reported as at-risk. Workers in several occupation and industry groups have a significantly higher risk of UBC, particularly when duration of employment is 10 years or more.
背景
对于许多职业，膀胱癌（UBC）的风险仍然存在不确定性。在这里，我们研究职业和行业与 UBC 之间的关联。
方法
对 604 名新诊断的 UBC 患者和 604 名癌症对照组进行了面对面访谈，收集了终生职业史。为每个工作职位分配了两位数的行业代码和三位数的职业代码。通过非条件逻辑回归计算了与从事工业或职业相关的 UBC 相关的比值比（OR），并根据年龄、性别和吸烟状况进行了调整。我们还检查了工业或职业就业年限（> 0 至< 10 年，≥ 10 年）与 UBC 风险之间的关系。
结果
观察到服务员和调酒师（OR 2.87；95%CI 1.05 至 7.72）以及与医学和健康相关的职业（OR 2.17；95%CI 1.21 至 3.92）、农业生产、畜牧业和动物专业（OR 1.90；95%CI 1.03 至 3.49）、电气装配、安装和维修（OR 1.69；95%CI 1.07 至 2.65）、通信（OR 1.74；95%CI 1.00 至 3.01）和卫生服务（OR 1.58；95%CI 1.02 至 2.44）的 UBC 风险显著增加。对于这些职业，我们还观察到长期工作（即> 10 年）与 UBC 风险显著增加，除了服务员和调酒师。从事 10 年或以上工作与一般农民（OR 9.58；95%CI 2.18 至 42.05）、农业作物生产（OR 3.36；95%CI 1.10 至 10.27）、与钳工相关的职业（OR 4.76；95%CI 1.74 至 13.01）、农业、渔业、林业和相关（OR 4.58；95%CI 1.97 至 10.65）、运输设备（OR 2.68；95%CI 1.03 至 6.97）和结构工作（OR 1.85；95%CI 1.16 至 2.95）的 UBC 风险增加相关。
结论
本研究为先前报告的风险职业与 UBC 风险增加提供了证据。从事某些职业和行业群体的工人患 UBC 的风险明显更高，尤其是当就业年限为 10 年或更长时间时。
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