Department of Biology, Belmont University; 1900 Belmont Boulevard, Nashville, TN 37212, USA.
Department of Pharmaceutical Sciences, College of Pharmacy, Belmont University; 1900 Belmont Boulevard, Nashville, TN 37212, USA.
Molecules. 2019 Apr 22;24(8):1580. doi: 10.3390/molecules24081580.
Cervical cancer is a major cause of death in females worldwide. While survival rates have historically improved, there remains a continuous need to identify novel molecules that are effective against this disease. Here, we show that enoxacin, a drug most commonly used to treat a broad array of bacterial infections, is able to inhibit growth of the cervical cancer cells. Furthermore, our data show that epigallocatechin gallate (EGCG), a plant bioactive compound abundant in green tea, and known for its antioxidant effects, similarly functions as an antiproliferative agent. Most importantly, we provide evidence that EGCG functions synergistically against cancer cell proliferation in combined treatment with enoxacin. These data collectively suggest that enoxacin and EGCG may be useful treatment options for cases of cervical cancer.
宫颈癌是全球女性死亡的主要原因之一。虽然生存率在历史上有所提高，但仍需要不断发现针对这种疾病有效的新分子。在这里，我们表明，以昔萘酸（一种最常用于治疗多种细菌感染的药物）能够抑制宫颈癌细胞的生长。此外，我们的数据表明，表没食子儿茶素没食子酸酯（EGCG），一种在绿茶中含量丰富的植物生物活性化合物，以其抗氧化作用而闻名，同样具有抗增殖作用。最重要的是，我们提供了证据表明，表没食子儿茶素没食子酸酯（EGCG）与以昔萘酸联合治疗时，对癌细胞增殖具有协同作用。这些数据表明，以昔萘酸和表没食子儿茶素没食子酸酯（EGCG）可能是宫颈癌治疗的有效选择。
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