新型合成促胰液素制剂与天然猪促胰液素在犬体内的生物活性比较。
Comparison of the biological potency of a new synthetic preparation of secretin with that of natural porcine secretin in the dog.
作者信息
Gyr K, Kayasseh L, Rittmann W W, Girard J, Stalder G A
出版信息
Gut. 1978 May;19(5):355-7. doi: 10.1136/gut.19.5.355.
Abstract
The biological activity of the new synthetic secretin, Roche, on exocrine pancreatic secretion was determined in conscious dogs with chronic gastric and duodenal fistulae and compared with that of pure porcine secretin (GIH, Karolinska Institutet, Stockholm). The two secretin preparations were found to be equipotent as to pancreatic volume and bicarbonate response on a molar basis. It was concluded that the new synthetic secretin is useful for clinical and research purposes.
摘要
在患有慢性胃瘘和十二指肠瘘的清醒犬中，测定了新型合成促胰液素（罗氏公司）对胰腺外分泌的生物活性，并与纯猪促胰液素（胃肠抑制肽，斯德哥尔摩卡罗林斯卡学院）进行了比较。发现这两种促胰液素制剂在摩尔基础上对胰腺体积和碳酸氢盐反应的效力相当。得出结论，新型合成促胰液素可用于临床和研究目的。
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Gastroenterology. 1968 Aug;55(2):260-7.
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[Synthesis of biologically fully-active secretin].
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