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新型合成促胰液素制剂与天然猪促胰液素在犬体内的生物活性比较。

Comparison of the biological potency of a new synthetic preparation of secretin with that of natural porcine secretin in the dog.

作者信息

Gyr K, Kayasseh L, Rittmann W W, Girard J, Stalder G A

出版信息

Gut. 1978 May;19(5):355-7. doi: 10.1136/gut.19.5.355.

DOI:10.1136/gut.19.5.355
PMID:658763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412102/
Abstract

The biological activity of the new synthetic secretin, Roche, on exocrine pancreatic secretion was determined in conscious dogs with chronic gastric and duodenal fistulae and compared with that of pure porcine secretin (GIH, Karolinska Institutet, Stockholm). The two secretin preparations were found to be equipotent as to pancreatic volume and bicarbonate response on a molar basis. It was concluded that the new synthetic secretin is useful for clinical and research purposes.

摘要

在患有慢性胃瘘和十二指肠瘘的清醒犬中，测定了新型合成促胰液素（罗氏公司）对胰腺外分泌的生物活性，并与纯猪促胰液素（胃肠抑制肽，斯德哥尔摩卡罗林斯卡学院）进行了比较。发现这两种促胰液素制剂在摩尔基础上对胰腺体积和碳酸氢盐反应的效力相当。得出结论，新型合成促胰液素可用于临床和研究目的。

相似文献

1
Comparison of the biological potency of a new synthetic preparation of secretin with that of natural porcine secretin in the dog.新型合成促胰液素制剂与天然猪促胰液素在犬体内的生物活性比较。
Gut. 1978 May;19(5):355-7. doi: 10.1136/gut.19.5.355.
2
Comparative effects of synthetic and natural secretin on pancreatic secretion and on secretin, insulin, and glucagon levels in man.合成促胰液素与天然促胰液素对人体胰腺分泌以及促胰液素、胰岛素和胰高血糖素水平的比较作用。
Dig Dis Sci. 1982 Mar;27(3):231-3. doi: 10.1007/BF01296921.
3
A new round in the discussion on the action of secretin on pancreatic protein secretion: a further study on the effect of secretin on pancreatic secretion in dogs.关于促胰液素对胰腺蛋白质分泌作用的讨论的新一轮：促胰液素对犬胰腺分泌影响的进一步研究。
Pancreas. 1987;2(4):422-6. doi: 10.1097/00006676-198707000-00009.
4
Influence of the vagus nerve on release and action of secretin in dog.迷走神经对犬促胰液素释放及作用的影响。
J Physiol. 1979 Aug;293:435-46. doi: 10.1113/jphysiol.1979.sp012898.
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Comparison of the actions of porcine secretin and extracts of chicken duodenum on pancreatic exocrine secretion in the cat and turkey.猪促胰液素与鸡十二指肠提取物对猫和火鸡胰腺外分泌的作用比较。
J Physiol. 1975 Jan;244(3):625-37. doi: 10.1113/jphysiol.1975.sp010816.
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Enkephalin inhibits the release and action of secretin on pancreatic secretion in the dog.脑啡肽抑制促胰液素对犬胰腺分泌的释放及作用。
J Physiol. 1980 Jan;298:429-36. doi: 10.1113/jphysiol.1980.sp013092.
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A comparison of Boots and GIH secretin as stimuli of pancreatic secretion in human subjects with or without chronic pancreatitis.在患有或未患有慢性胰腺炎的人类受试者中，比较Boots和胃肠道激素（GIH）促胰液素作为胰腺分泌刺激物的情况。
Gut. 1972 Sep;13(9):721-5. doi: 10.1136/gut.13.9.721.
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Physiological significance of secretin in the pancreatic bicarbonate secretion. II. Pancreatic bicarbonate response to a physiological increase in plasma secretin concentration.促胰液素在胰腺碳酸氢盐分泌中的生理意义。II. 胰腺碳酸氢盐对血浆促胰液素浓度生理性升高的反应
Scand J Gastroenterol. 1979;14(1):85-90. doi: 10.3109/00365527909179850.
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Secretory effects of secretin on isolated perfused porcine pancreas.促胰液素对离体灌注猪胰腺的分泌作用。
Am J Physiol. 1978 Oct;235(4):E381-6. doi: 10.1152/ajpendo.1978.235.4.E381.
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[Comparison of the effects of natural and synthetic secretin on the exocrine secretion of the human pancreas (author's transl)].天然与合成促胰液素对人体胰腺外分泌作用的比较（作者译）
Z Gastroenterol. 1980 Dec;18(12):625-32.

引用本文的文献

1
Exocrine pancreatic function tests.外分泌胰腺功能测试
Gut. 1982 Sep;23(9):777-98. doi: 10.1136/gut.23.9.777.
2
Comparative effects of synthetic and natural secretin on pancreatic secretion and on secretin, insulin, and glucagon levels in man.合成促胰液素与天然促胰液素对人体胰腺分泌以及促胰液素、胰岛素和胰高血糖素水平的比较作用。
Dig Dis Sci. 1982 Mar;27(3):231-3. doi: 10.1007/BF01296921.
3
Neurotensin-like immunoreactivity in some preparations of secretin and cholecystokinin.在某些促胰液素和胆囊收缩素制剂中的神经降压素样免疫反应性。
Agents Actions. 1985 Jul;16(5):411-4. doi: 10.1007/BF01982882.
4
Exogenous and endogenous stimulations during different phases of pancreatic secretion in conscious rats.清醒大鼠胰腺分泌不同阶段的外源性和内源性刺激
Pflugers Arch. 1979 Dec;383(1):19-27. doi: 10.1007/BF00584470.
5
Immunological blocking of exogenous and endogenous secretin in the dog.犬中外源性和内源性促胰液素的免疫阻断。
Experientia. 1979 Dec 15;35(12):1596-7. doi: 10.1007/BF01953214.

本文引用的文献

1
Synthesis of a heptacosapeptide amide with the hormonal activity of sccretin.具有促胰液素激素活性的二十七肽酰胺的合成。
Chem Ind. 1966 Oct 15;42:1757-8.
2
Synthetic secretin: comparison with natural secretin for potency and spectrum of physiological actions.合成促胰液素：与天然促胰液素在生理作用效能和范围上的比较。
Gastroenterology. 1968 Aug;55(2):260-7.
3
[Synthesis of biologically fully-active secretin].
Naturwissenschaften. 1972 Jun;59(6):239-46. doi: 10.1007/BF00610198.
4
Comparison of synthetic and natural porcine secretins on human pancreatic secretion.合成猪促胰液素与天然猪促胰液素对人体胰腺分泌的比较。
Gastroenterology. 1974 Feb;66(2):204-9.