Schaffalitzky de Muckadell O B, Fahrenkrug J, Matzen P, Rune S J, Worning H
Scand J Gastroenterol. 1979;14(1):85-90. doi: 10.3109/00365527909179850.
The pancreatic response to physiological concentrations of secretin obtained after minute boluses of exogenous secretin was studied in 16 normal volunteers. Output of bicarbonate into the duodenum was measured by duodenal aspiration in 5 subjects and by endoscopic cannulation of the pancreatic duct in 11 subjects. Pure natural porcine secretin was injected intravenously in doses of 125, 250, and 500 fmol x kg-1 body weight (0.0013, 0.0027, and 0.0054 clinical units x kg-1). All three doses of secretin increased plasma secretin concentration, duodenal bicarbonate concentration, and duodenal bicarbonate output significantly. The bicarbonate output measured by the two techniques did not differ significantly. The increments in median plasma secretin concentration were 1.6, 3.0, and 6.4 pmol x 1(-1) after secretin, 125, 250 and 500 fmol x kg-1, and the corresponding 15-min bicarbonate output 283, 442, and 1435 micromol, respectively. The concentrations of secretin in plasma found after these doses of secretin are of the same order of magnitude as the secretin concentrations found during physiological conditions in man. It is concluded that the physiological concentrations or secretin influence pancreatic bicarbonate secretion.
在16名正常志愿者中研究了胰腺对外源性促胰液素小剂量推注后生理浓度促胰液素的反应。5名受试者通过十二指肠抽吸法、11名受试者通过内镜下胰管插管法测量十二指肠中碳酸氢盐的排出量。以125、250和500 fmol×kg-1体重（0.0013、0.0027和0.0054临床单位×kg-1）的剂量静脉注射纯天然猪促胰液素。所有三种剂量的促胰液素均显著提高了血浆促胰液素浓度、十二指肠碳酸氢盐浓度和十二指肠碳酸氢盐排出量。两种技术测量的碳酸氢盐排出量无显著差异。促胰液素剂量为125、250和500 fmol×kg-1时，血浆促胰液素浓度中位数的增量分别为1.6、3.0和6.4 pmol×l-1，相应的15分钟碳酸氢盐排出量分别为283、442和1435 μmol。这些促胰液素剂量后血浆中促胰液素的浓度与人体生理状态下发现的促胰液素浓度处于同一数量级。得出的结论是，促胰液素的生理浓度会影响胰腺碳酸氢盐的分泌。
