儿童淋巴细胞白血病：6-巯基嘌呤利用的性别差异。
Childhood lymphoblastic leukaemia: sex difference in 6-mercaptopurine utilization.
作者信息
Lilleyman J S, Lennard L, Rees C A, Morgan G, Maddocks J L
出版信息
Br J Cancer. 1984 Jun;49(6):703-7. doi: 10.1038/bjc.1984.111.
Abstract
Twelve boys and 10 girls on similar long term remission maintenance treatment for lymphoblastic leukaemia had 79 random assays of their red cell 6 thioguanine nucleotide ( 6TGN ) concentrations performed as an index of cytotoxic activity generated by oral 6-mercaptopurine ( 6MP ). Correlation between the dose of 6MP and 6TGN was statistically significant in the girls (r = 0.58, P less than 0.001) but not in the boys (r = 0.15). Additionally, as a group the boys tolerated more 6MP (P less than 0.05), despite similar prescribing criteria, but this did not result in a higher mean 6TGN concentration or increased myelotoxicity. It appears that girls develop 6MP cytotoxicity at lower doses and more predictably than boys. If so, this may be relevant to the as yet unexplained but marked sex difference in prognosis apparent in some studies.
摘要
12名男孩和10名女孩接受了类似的针对淋巴细胞白血病的长期缓解维持治疗，对他们的红细胞6-硫鸟嘌呤核苷酸（6TGN）浓度进行了79次随机检测，以此作为口服6-巯基嘌呤（6MP）产生的细胞毒性活性指标。女孩中6MP剂量与6TGN之间的相关性具有统计学意义（r = 0.58，P < 0.001），而男孩中则无统计学意义（r = 0.15）。此外，尽管处方标准相似，但作为一个群体，男孩耐受的6MP更多（P < 0.05），但这并未导致更高的平均6TGN浓度或骨髓毒性增加。似乎女孩比男孩在更低剂量时就能产生6MP细胞毒性，且更具可预测性。如果是这样，这可能与一些研究中尚未解释清楚但明显的预后性别差异有关。
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