嗅闻雄烯酮的能力由基因决定。
Ability to smell androstenone is genetically determined.
作者信息
Wysocki C J, Beauchamp G K
出版信息
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4899-902. doi: 10.1073/pnas.81.15.4899.
Abstract
Some adult humans cannot detect the odor of androstenone (5 alpha-androst-16-en-3-one), a volatile steroid. To test for the presence of genetic variance associated with this trait, adult twins were tested for their ability to smell androstenone and another odorant, pyridine, that is readily perceived by most adults. Ascending concentration, two-sample (odor versus blank) forced choice tests were used to assess sensitivity to these odorants. Intraclass correlations for identical and fraternal twin detection thresholds to pyridine were small and not significantly different. However, intraclass correlations for thresholds to androstenone were significantly different, with the correlation for identical twins being greater than that for the fraternal twins. These data indicate a genetic component of variation in sensitivity to this odor. Investigations that use genetic variation could offer a new tool for studies of olfactory transduction mechanisms.
摘要
一些成年人无法察觉雄烯酮（5α-雄甾-16-烯-3-酮）的气味，这是一种挥发性类固醇。为了测试与该性状相关的遗传变异的存在，对成年双胞胎进行了嗅觉测试，检测他们闻雄烯酮以及另一种大多数成年人都能轻易察觉的气味剂吡啶的能力。采用浓度递增的双样本（气味与空白对照）强迫选择测试来评估对这些气味剂的敏感性。同卵双胞胎和异卵双胞胎对吡啶检测阈值的组内相关性较小且无显著差异。然而，对雄烯酮阈值的组内相关性存在显著差异，同卵双胞胎的相关性大于异卵双胞胎。这些数据表明对这种气味敏感性变化存在遗传成分。利用遗传变异的研究可为嗅觉转导机制的研究提供一种新工具。
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本文引用的文献
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