Pollack M S, Wysocki C J, Beauchamp G K, Braun D, Callaway C, Dupont B
Immunogenetics. 1982;15(6):579-89. doi: 10.1007/BF00347052.
Sensitivity to the odor of 5-androst-16-en-3-one (androstenone), a testosterone metabolite, shows wide variations among unrelated individuals. Analysis of correlations in sensitivity between monozygotic twin pairs, dizygotic twin pairs, and nontwin sib pairs now shows that at least a portion of this variation is genetically determined. However, although data from some mouse studies have suggested a relationship between olfaction and the murine histocompatibility system (H-2), we were unable to demonstrate any role of the human HLA system in explaining the wide individual variations in human sensitivity to androstenone. An additional analysis of HLA antigens among 61 human mating pairs also provided no evidence that HLA phenotypes play a role in human mating preference. These data fail to support a role for the human HLA system in the recognition of an odorant of potential biological significance.
对睾酮代谢产物5-雄甾-16-烯-3-酮（雄烯酮）气味的敏感度在无血缘关系的个体间存在很大差异。对同卵双胞胎、异卵双胞胎以及非双胞胎同胞对之间敏感度相关性的分析表明，这种差异至少有一部分是由基因决定的。然而，尽管一些小鼠研究的数据表明嗅觉与小鼠组织相容性系统（H-2）之间存在关联，但我们无法证明人类HLA系统在解释人类对雄烯酮敏感度的广泛个体差异中发挥任何作用。对61对人类配偶的HLA抗原进行的额外分析也没有提供证据表明HLA表型在人类择偶偏好中起作用。这些数据不支持人类HLA系统在识别具有潜在生物学意义的气味剂中发挥作用。
