Hambrecht G S, Hilton J G
Prostaglandins Leukot Med. 1984 Jun;14(3):297-304. doi: 10.1016/0262-1746(84)90113-6.
The effects of scald injury and scald injury with pretreatment on plasma and water content were studied in the superfused hamster cheek pouch. Catalase (30,000 Units/kg), indomethacin (2.5 mg/kg) and FPL 55712 (2 mg/kg) were administered prior to 10 second scald with 100 degrees C normal saline. Plasma content was measured with 125 I serum albumin and water content was calculated by loss on drying. Significant (P less than 0.05) decreases in plasma content compared to scald alone were observed following pretreatment with catalase (29%) indomethacin (31%) or FPL 55712 (52%). Water content in scalded pouches was significantly reduced by catalase (29%) and FPL 55712 (42%). Pretreatment when combined also resulted in significant reduction of plasma content but not water content. Results suggest that free-radicals, prostaglandins and leukotrienes are involved in vascular response by scald injury.
在体外灌注的仓鼠颊囊中研究了烫伤以及预处理后烫伤对血浆和含水量的影响。在用100℃生理盐水进行10秒烫伤之前，给予过氧化氢酶（30,000单位/千克）、吲哚美辛（2.5毫克/千克）和FPL 55712（2毫克/千克）。用125I血清白蛋白测量血浆含量，并通过干燥失重计算含水量。与单纯烫伤相比，在用过氧化氢酶（29%）、吲哚美辛（31%）或FPL 55712（52%）预处理后，观察到血浆含量显著（P<0.05）降低。过氧化氢酶（29%）和FPL 55712（42%）可显著降低烫伤颊囊的含水量。联合预处理也可显著降低血浆含量，但对含水量无影响。结果表明，自由基、前列腺素和白三烯参与了烫伤引起的血管反应。
