Pindborg J J, Murti P R, Bhonsle R B, Gupta P C, Daftary D K, Mehta F S
Scand J Dent Res. 1984 Jun;92(3):224-9. doi: 10.1111/j.1600-0722.1984.tb00883.x.
An evaluation of the malignant potential of submucous fibrosis, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India was done. Out of the 89 patients, 12 were referred patients and 77 were diagnosed in population based studies. At the time of first examination oral cancer was found to be coexistent in nine (10%) cases. For 66 patients follow-up observations ranging from 4 to 15 yr (median 8 yr) were available. During this period malignant transformation was observed in three patients (4.5%). Considering malignant transformation and coexistence together, oral cancer was observed in 13% of the present material. Leukoplakia was found in 26% of the patients with submucous fibrosis. Out of 42 submucous fibrosis patients biopsied, 12% showed squamous cell carcinoma, 26% epithelial dysplasia, and 76% atrophic epithelium. These findings reinforced the hypothesis that submucous fibrosis is a precancerous condition.
基于对印度喀拉拉邦埃尔讷古勒姆地区89例该疾病患者的观察，对黏膜下纤维化的恶性潜能进行了评估。在这89例患者中，12例为转诊患者，77例是在基于人群的研究中确诊的。首次检查时，发现9例（10%）患者同时存在口腔癌。66例患者有4至15年（中位值8年）的随访观察数据。在此期间，3例患者（4.5%）发生了恶性转化。综合考虑恶性转化和同时存在的情况，在本研究资料中，口腔癌的发生率为13%。黏膜下纤维化患者中26%发现有白斑。在42例行活检的黏膜下纤维化患者中，12%显示为鳞状细胞癌，26%为上皮发育异常，76%为萎缩性上皮。这些发现强化了黏膜下纤维化是一种癌前病变的假说。
