肥大细胞在口腔黏膜下纤维性变发病机制中的作用：系统评价和荟萃分析。

Role of mast cells in the pathogenesis of oral submucous fibrosis: a systematic review and meta-analysis.

机构信息

Maxillofacial Surgery and Diagnostic Sciences Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 11426, Saudi Arabia.

King Abdullah International Medical Research Centre, Ministry of National Guard Health Affairs, Riyadh, 11481, Saudi Arabia.

出版信息

BMC Oral Health. 2024 Oct 14;24(1):1219. doi: 10.1186/s12903-024-05025-8.

DOI:10.1186/s12903-024-05025-8

PMID:39402549

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476548/

Abstract

BACKGROUND

Oral Submucous Fibrosis (OSMF) is an oral potentially malignant disorder (OPMD) that commonly occurs in the South Asian population as there is high usage of areca nut. There has been extensive research on the pathogenesis and treatment of this condition. It is well-established in the scientific literature that mast cells (MC) have a definitive role in several inflammatory disorders. OSMF being a chronic inflammatory disorder, is also expected to have increased MCs. Hence, this review aims to evaluate the role of MCs in the pathogenesis of OSMF.

METHODS

A systematic search of articles was performed by two of the authors independently in PubMed, Scopus, Embase, Web of Science, and Google Scholar using the appropriate keywords and Boolean terms. The risk of bias was assessed using the Modified Newcastle-Ottawa Scale. The meta-analysis was performed with R studio software (Version: 4.4.0, Year: 2024, Company: The R foundation for statistical computing).

RESULTS

The search retrieved 36 studies, of which 16 were suitable for the review. There is evidence for a marked increase in the number of MCs in OSMF than the normal mucosa upon analyzing the retrieved articles. However, when comparing the grades of OSMF, there are variations in the reports. As all the retrieved articles were case-control studies, the risk of bias was analyzed using the Modified New Castle Ottawa Scale. All the studies scored in the good category (Score 6-9). The pooled effect size shows the Standard Mean Deviation (SMD) to be 0.09, 95% confidence interval (CI) [-0.18;0.37] to lie on either side of no effect. Hence the role of MCs in OSMF has not been established because of homogeneity and consistent sampling error.

CONCLUSION

Our systematic review does suggest a definitive role of mast cells in the progression of OSMF. However, there is a lack of methodological rigor in the included studies. This may contribute to diluting the results.

摘要

背景

口腔黏膜下纤维性变（OSMF）是一种口腔潜在恶性疾病（OPMD），在南亚人群中较为常见，因为他们大量食用槟榔。对于这种疾病的发病机制和治疗方法已经进行了广泛的研究。科学文献中已经明确，肥大细胞（MC）在几种炎症性疾病中具有明确的作用。OSMF 作为一种慢性炎症性疾病，预计也会有更多的 MC。因此，本综述旨在评估 MC 在 OSMF 发病机制中的作用。

方法

两名作者独立在 PubMed、Scopus、Embase、Web of Science 和 Google Scholar 中使用适当的关键词和布尔术语进行了文章的系统搜索。使用改良的 Newcastle-Ottawa 量表评估偏倚风险。使用 R 工作室软件（版本：4.4.0，年份：2024，公司：R 基金会进行统计计算）进行荟萃分析。

结果

搜索共检索到 36 项研究，其中 16 项适合综述。通过分析检索到的文章，发现 OSMF 中的 MC 数量明显多于正常黏膜。然而，当比较 OSMF 的等级时，报告存在差异。由于所有检索到的文章都是病例对照研究，因此使用改良的纽卡斯尔-渥太华量表分析了偏倚风险。所有研究的评分均为良好类别（得分 6-9）。汇总效应大小显示标准均数差（SMD）为 0.09，95%置信区间（CI）[-0.18；0.37]位于无效应的两侧。因此，由于同质性和一致的抽样误差，MC 在 OSMF 中的作用尚未确定。