Stehbens J A, Kisker C T
J Dev Behav Pediatr. 1984 Aug;5(4):184-8.
Intellectual and educational testing, employing primarily the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the Wide Range Achievement Test (WRAT), was administered to two groups of children, one with acute lymphoblastic leukemia (ALL), the other with a solid tumor (ST) which did not invade or involve the central nervous system (CNS). Initial testing was completed within 30 days following diagnosis and repeated one year and three years later. Separate ANOVA procedures on the ALL and ST patients were completed, with followup ANOVA procedures for two age groups. The ALL patients declined significantly on WISC-R vocabulary (p less than 0.05) and Full Scale IQ (p less than 0.05), but no significant changes were obtained from the ST patients. Separation of the ALL group into two age groups, less than 8 years and greater than or equal to 8 years revealed significant declines in the younger group on Verbal IQ, Performance IQ, Full Scale IQ, and WRAT arithmetic. However, no significant declines were observed in the older ALL group. The results suggest that declines in ability and achievement are limited to those ALL patients treated with CNS prophylaxis at relatively young ages.
对两组儿童进行了智力和教育测试，主要采用韦氏儿童智力量表修订版（WISC-R）和广泛成就测验（WRAT），一组患有急性淋巴细胞白血病（ALL），另一组患有实体瘤（ST），该实体瘤未侵犯或累及中枢神经系统（CNS）。初始测试在诊断后30天内完成，并在一年和三年后重复进行。对ALL和ST患者分别进行了方差分析程序，并对两个年龄组进行了后续方差分析程序。ALL患者在WISC-R词汇量（p<0.05）和全量表智商（p<0.05）上显著下降，但ST患者未出现显著变化。将ALL组分为小于8岁和大于或等于8岁两个年龄组，结果显示较年轻组在言语智商、操作智商、全量表智商和WRAT算术方面显著下降。然而，年龄较大的ALL组未观察到显著下降。结果表明，能力和成就的下降仅限于那些在相对年轻时接受中枢神经系统预防治疗的ALL患者。
