Kurka M, Orfanos C E, Pullmann H
Hautarzt. 1978 Jun;29(6):313-8.
15 patients with superficial basaliomas or premalignant epithelial neoplastic disorders (actinic keratosis, leukoplakia, Bowen's disease) were treated locally over three weeks with retinoic acid (RA) alone or in combination with 5-fluorouracil (5-FU). In 11 cases the lesions disappeared clinically, however, only 5 patients proved to be cured by histological examination. 4 of them were treated with RA combined with 5-FU. There was a decrease of the 3H-index after the first week and an increase after the third week of treatment. These findings suggest, that RA inhibits the proliferation of neoplastic keratinocytes and stimulates the proliferation of normal epidermal cells. Retinoic acid, therefore, has an inhibitory effect on epithelial neoplasias, particularly in combination with 5-FU. Since local therapy with RA and 5-FU is not sufficient for routine clinical purposes in all cases, their use should be restricted to selected patients.
15例浅表性基底细胞瘤或上皮性肿瘤前疾病（光化性角化病、白斑病、鲍恩病）患者，在三周内单独使用维甲酸（RA）或与5-氟尿嘧啶（5-FU）联合进行局部治疗。11例患者的皮损临床消失，但经组织学检查仅5例治愈。其中4例接受RA联合5-FU治疗。治疗第一周后3H指数下降，第三周后上升。这些发现表明，RA抑制肿瘤角质形成细胞的增殖并刺激正常表皮细胞的增殖。因此，维甲酸对上皮性肿瘤有抑制作用，尤其是与5-FU联合使用时。由于RA和5-FU的局部治疗在所有情况下都不足以满足常规临床需求，因此它们的使用应仅限于特定患者。
