Westaby D, Williams R
Scand J Gastroenterol Suppl. 1984;102:71-5.
In a prospective study, 200 patients with variceal bleeding (179 cirrhosis, 21 noncirrhotic) who were treated by long-term sclerotherapy were followed for periods up to 6 years. Varices were obliterated in 162 (81%) with a median of four courses of injection. 'New' varices developed in 99 cases and were a cause of bleeding in 28, of whom 3 died. The recurrence of varices was almost always observed within 12 months of initial obliteration. A median of two courses of sclerotherapy were required to again achieve obliteration. In 20 patients a second recurrence of varices occurred with bleeding in 8 cases but no associated deaths. Based on these observations we recommend regular follow-up endoscopy after obliteration, particularly in the 1st year, to detect and treat varices before they are a cause of bleeding.
在一项前瞻性研究中，对200例接受长期硬化疗法治疗的静脉曲张出血患者（179例肝硬化患者，21例非肝硬化患者）进行了长达6年的随访。162例（81%）的静脉曲张被消除，注射疗程中位数为4个疗程。99例出现“新的”静脉曲张，其中28例因静脉曲张出血，3例死亡。静脉曲张复发几乎总是在首次消除后的12个月内出现。再次实现消除需要进行中位数为2个疗程的硬化疗法。20例患者静脉曲张第二次复发，8例出血，但无相关死亡病例。基于这些观察结果，我们建议在静脉曲张消除后定期进行随访内镜检查，尤其是在第1年，以便在静脉曲张导致出血之前进行检测和治疗。
