硬皮病（系统性硬化症）患者及其血亲与配偶体内的抗核抗体
Antinuclear antibodies in patients with scleroderma (systemic sclerosis) and in their blood relatives and spouses.
作者信息
Barnett A J, McNeilage L J
机构信息
Alfred Hospital, Melbourne, Australia.
出版信息
Ann Rheum Dis. 1993 May;52(5):365-8. doi: 10.1136/ard.52.5.365.
OBJECTIVE
To test the postulate that there is a higher prevalence of antinuclear antibodies (ANAs) in serum samples from blood relatives and from spouses of patients with scleroderma than in control samples, and that this provides evidence for both genetic and environmental factors influencing autoimmunity in scleroderma.
METHOD
Testing for ANAs was performed on 58 patients with scleroderma, 30 of their spouses, 74 first degree relatives, and 66 control subjects broadly age matched to the patients, their spouses, and about half of the relatives (siblings and parents).
RESULTS
On the basis of an ANA titre of > 40 as positive, 12 (18%) of the controls, 55 (95%) of the patients, one (3%) of the spouses and five (7%) of the relatives would be classified as positive. Thirty seven (64%) of the patients had defined specificities (ACA, Scl 70, U1 (RNP)) but none of the controls, spouses, or relatives had antibodies of these specificities.
CONCLUSION
These findings give no support to the postulate that environmental or genetic factors contribute to the ANAs in scleroderma.
目的
验证以下假设，即硬皮病患者的血亲及配偶血清样本中抗核抗体（ANA）的患病率高于对照样本，且这为影响硬皮病自身免疫的遗传和环境因素提供了证据。
方法
对58例硬皮病患者、30例其配偶、74例一级亲属以及66名与患者、其配偶及约一半亲属（兄弟姐妹和父母）年龄大致匹配的对照对象进行ANA检测。
结果
以ANA滴度>40为阳性标准，12名（18%）对照对象、55名（95%）患者、1名（3%）配偶和5名（7%）亲属可被分类为阳性。37名（64%）患者具有明确的特异性（ACA、Scl 70、U1（RNP）），但对照对象、配偶或亲属均无这些特异性抗体。
结论
这些发现不支持环境或遗传因素导致硬皮病中ANA产生的假设。
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