MacLean C J, Morton N E, Yee S
Comput Biomed Res. 1984 Oct;17(5):471-80. doi: 10.1016/0010-4809(84)90013-2.
For traits with incomplete penetrance, simultaneous segregation analysis and linkage analysis may offer increased information. Since the numerical properties of the mixed model are a drawback in this more complicated analysis, a second locus is substituted for the polygenic component yielding a simpler and more tractable oligogenic model. While less realistic, the simpler model is not easily discriminated from the mixed model, particularly when used on affection data rather than quantitative traits. Calculations for combined linkage and segregation analysis are described for nuclear families with pointers to account for sampling scheme.
对于具有不完全外显率的性状，同时进行分离分析和连锁分析可能会提供更多信息。由于混合模型的数值特性在这种更复杂的分析中是一个缺点，因此用第二个基因座替代多基因成分，从而产生一个更简单、更易于处理的寡基因模型。虽然不太现实，但这个更简单的模型不容易与混合模型区分开来，特别是当用于患病数据而非数量性状时。本文描述了针对核心家庭的联合连锁和分离分析的计算方法，并给出了考虑抽样方案的提示。
