Morton N E
Human Genetics, Princess Anne Hospital, Southampton, United Kingdom.
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3471-6. doi: 10.1073/pnas.93.8.3471.
Lod scores provide a method to unify linkage tests based on identity by descent and identity in marker state while permitting selection of the most informative individuals through their disease-related phenotypes and markers in relatives. After parametric lods are reviewed, a nonparametric approach that depends on a single logistic parameter beta is introduced. Lods for parents tested or unknown are derived, multiple pairwise mapping is presented, and power is shown to be good even for moderately small values of beta. Comparison of parametric and nonparametric approaches (yet to be made) will provide for polygenes the efficiency and reliability that lod scores gave to mapping of major loci 40 years ago.
对数优势分数提供了一种方法，可将基于血统一致性和标记状态一致性的连锁测试统一起来，同时允许通过个体的疾病相关表型及其亲属的标记来选择信息最丰富的个体。在回顾了参数化对数优势分数之后，引入了一种依赖于单个逻辑参数β的非参数方法。推导出了针对已检测或未知亲本的对数优势分数，提出了多重成对映射，并且即使对于β的适度小值，功效也显示良好。参数化方法和非参数化方法的比较（尚未进行）将为多基因提供40年前对数优势分数赋予主要基因座定位的效率和可靠性。
