使用遗传混合模型的替代公式进行连锁分析：有限多基因混合模型。
Linkage analysis with an alternative formulation for the mixed model of inheritance: the finite polygenic mixed model.
作者信息
Stricker C, Fernando R L, Elston R C
机构信息
Institute of Animal Sciences, Swiss Federal Institute of Technology, ETH-Zentrum CLU, Zuerich, Switzerland.
出版信息
Genetics. 1995 Dec;141(4):1651-6. doi: 10.1093/genetics/141.4.1651.
Abstract
This paper presents an extension of the finite polygenic mixed model of Fernando et al. (1994) to linkage analysis. The finite polygenic mixed model, extended for linkage analysis, leads to a likelihood that can be calculated using efficient algorithms developed for oligogenic models. For comparison, linkage analysis of 5 simulated 4021-member pedigrees was performed using the usual mixed model of inheritance, approximated by Hasstedt (1982), and the finite polygenic mixed model extended for linkage analysis presented here. Maximum likelihood estimates of the finite polygenic mixed model could be inferred to be closer to the simulated values in these pedigrees.
摘要
本文介绍了费尔南多等人（1994年）的有限多基因混合模型在连锁分析中的扩展。扩展用于连锁分析的有限多基因混合模型，得到了一个似然值，该似然值可以使用为寡基因模型开发的高效算法来计算。为了进行比较，使用哈斯泰德（1982年）近似的通常遗传混合模型以及本文介绍的扩展用于连锁分析的有限多基因混合模型，对5个模拟的4021成员家系进行了连锁分析。可以推断，在这些家系中，有限多基因混合模型的最大似然估计值更接近模拟值。
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