Liò P, Morton N E
Human Genetics, University of Southampton, Princess Anne Hospital, Level G, Coxford Road, Southampton, United Kingdom.
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5344-8. doi: 10.1073/pnas.94.10.5344.
A sample of 95 sib pairs affected with insulin-dependent diabetes and typed with their normal parents for 28 markers on chromosome 6 has been analyzed by several methods. When appropriate parameters are efficiently estimated, a parametric model is equivalent to the beta model, which is superior to nonparametric alternatives both in single point tests (as found previously) and in multipoint tests. Theory is given for meta-analysis combined with allelic association, and problems that may be associated with errors of map location and/or marker typing are identified. Reducing by multipoint analysis the number of association tests in a dense map can give a 3-fold reduction in the critical lod, and therefore in the cost of positional cloning.
对95对患胰岛素依赖型糖尿病的同胞对及其正常父母进行了6号染色体上28个标记的分型，并采用多种方法进行了分析。当有效估计适当参数时，参数模型等同于β模型，该模型在单点检验（如先前发现的那样）和多点检验中均优于非参数替代方法。给出了荟萃分析与等位基因关联相结合的理论，并识别了可能与图谱定位和/或标记分型错误相关的问题。通过多点分析减少密集图谱中关联检验的数量，可以使临界对数优势比降低3倍，从而降低定位克隆的成本。
