微管末端GTP帽相变动力学的初步分析。
Introductory analysis of the GTP-cap phase-change kinetics at the end of a microtubule.
作者信息
Hill T L
出版信息
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6728-32. doi: 10.1073/pnas.81.21.6728.
Abstract
An introductory analysis is provided for the two-phase macroscopic kinetic model of the end of a microtubule. Some general relations are derived for one end of a very long microtubule in solution but the main results refer to the steady-state properties of microtubules grown on nucleated sites, as in the experiments of Mitchison and Kirschner [Mitchison, T. & Kirschner, M. W. (1984) Nature (London), in press]. The two-phase model makes it possible to understand qualitatively how long microtubules can grow well below the critical concentration and also how grown microtubules can rapidly disappear from a nucleated site by shortening following a phase change.
摘要
本文对微管末端的两相宏观动力学模型进行了初步分析。文中推导了溶液中很长微管一端的一些一般关系，但主要结果是关于在成核位点上生长的微管的稳态特性，就像米奇森和基尔希纳实验中的情况一样[米奇森，T. & 基尔希纳，M. W.（1984）《自然》（伦敦），即将发表]。两相模型使得定性理解长微管如何能在远低于临界浓度的情况下良好生长，以及已生长的微管如何能在相变后通过缩短而迅速从成核位点消失成为可能。
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