溶液中微管消失的理论处理。
Theoretical treatment of microtubules disappearing in solution.
作者信息
Chen Y, Hill T L
出版信息
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4127-31. doi: 10.1073/pnas.82.12.4127.
Abstract
The origin of the two-phase (cap, no cap) macroscopic kinetic model of the end of a microtubule is reviewed. The model is then applied to a new theoretical problem, namely, the Mitchison-Kirschner [Mitchison, T. & Kirschner, M. W. (1984) Nature (London) 312, 237-242] experiment in which aggregated microtubules in solution spontaneously decrease in number (shorten to disappearance) while the surviving microtubules increase in length. The model fits the experiments without difficulty.
摘要
综述了微管末端两相（帽状、无帽状）宏观动力学模型的起源。然后将该模型应用于一个新的理论问题，即米奇森 - 基尔希纳[米奇森，T. 和基尔希纳，M. W.（1984年）《自然》（伦敦）312卷，237 - 242页]实验，在该实验中，溶液中聚集的微管数量自发减少（缩短至消失），而存活的微管长度增加。该模型轻松拟合了实验结果。
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