Hirose M, Maki M, Chiba H
J Biochem. 1978 Apr;83(4):1205-7. doi: 10.1093/oxfordjournals.jbchem.a132013.
The template activities of chromatin isolated from virgin, pregnant, lactating, and regressed rat mammary glands were compared by using exogenously added bacterial and mammalian RNA polymerases. Template activity increased during the stage of pregnancy, then decreased during the stage from early lactation to regression. It showed the highest level at early lactation when intracellular levels of rRNA and mRNA are known to be at their maximums. These results suggest that transcriptional activity in the mammary gland is regulated, at least in part, by a modulation of chromatin template activity.
通过使用外源添加的细菌和哺乳动物RNA聚合酶，比较了从处女、怀孕、哺乳和退化的大鼠乳腺中分离出的染色质的模板活性。模板活性在怀孕阶段增加，然后在从早期泌乳到退化的阶段降低。在早期泌乳时其水平最高，此时已知细胞内rRNA和mRNA的水平处于最大值。这些结果表明，乳腺中的转录活性至少部分是通过染色质模板活性的调节来调控的。
