Lewis R V, Stern A S, Kilpatrick D L, Gerber L D, Rossier J, Stein S, Udenfriend S
J Neurosci. 1981 Jan;1(1):80-2. doi: 10.1523/JNEUROSCI.01-01-00080.1981.
When rat adrenal glands are denervated, large increases in the amounts of enkephalin and enkephalin-containing polypeptides appear. In the normal gland, only trace amounts occur. One of the larger polypeptides (approximately 22,000 daltons) increases rapidly and by 48 hr following denervation, attains 20 times its original level. At this time, the levels of free enkephalins are essentially unchanged. By 96 hr, the 22,000-dalton polypeptide begins to decrease as free enkephalins and intermediate-sized enkephalin-containing polypeptides increase. This series of events is consistent with a precursor (22,000-dalton polypeptide)/product (enkephalin) relationship.
当大鼠肾上腺去神经支配后，脑啡肽和含脑啡肽的多肽量会大幅增加。在正常腺体中，仅存在痕量。其中一种较大的多肽（约22,000道尔顿）在去神经支配后迅速增加，到48小时时，达到其原始水平的20倍。此时，游离脑啡肽的水平基本不变。到96小时时，22,000道尔顿的多肽开始减少，同时游离脑啡肽和中等大小的含脑啡肽多肽增加。这一系列事件与前体（22,000道尔顿的多肽）/产物（脑啡肽）关系一致。
