Kilpatrick D C, Dewar A E, Stockdill G, Maginnis M, Jordan A, Neill G W, Gelsthorpe K, Yap P L
Scand J Haematol. 1984 Oct;33(4):391-6. doi: 10.1111/j.1600-0609.1984.tb00713.x.
A series of 57 patients with chronic lymphocytic leukaemia was typed for HLA-A, B and DR antigens and compared with a control population of equal size. There was an increased frequency of HLA-A1 and B8 in the patient group, although it was not statistically significant after allowance for the number of specificities tested. A subgroup of patients lacking both A1 and B8 differed from the others in sex ratio, degree of lymphocytosis and incidence of hypogammaglobulinaemia at presentation. This subgroup also had less need for treatment within 6 months of presentation. While these findings must be considered preliminary, it is possible that tissue typing may help to identify patients with a relatively benign form of the disease.
对57例慢性淋巴细胞白血病患者进行了HLA - A、B和DR抗原分型，并与同等规模的对照人群进行比较。患者组中HLA - A1和B8的频率增加，尽管在考虑所检测的特异性数量后，这一差异无统计学意义。既缺乏A1又缺乏B8的患者亚组在性别比例、淋巴细胞增多程度和就诊时低丙种球蛋白血症的发生率方面与其他患者不同。该亚组在就诊后6个月内也较少需要治疗。虽然这些发现必须被视为初步结果，但组织分型有可能有助于识别病情相对良性的患者。
