人类Ⅱ型前胶原基因（COL2A1）定位于第12号染色体。

Localization of human type II procollagen gene (COL2A1) to chromosome 12.

作者信息

Strom C M, Eddy R L, Shows T B

出版信息

Somat Cell Mol Genet. 1984 Nov;10(6):651-5. doi: 10.1007/BF01535232.

DOI:10.1007/BF01535232

Abstract

DNA was prepared from 39 human-mouse somatic cell hybrid lines, and mouse and human parental cell lines. The DNA was digested to completion with EcoRI and Southern filters were prepared. These filters were hybridized at high stringency conditions to the human genomic subclone phHCol(II) A which corresponds to the human alpha 1(type II) procollagen gene (COL2A1). The mouse DNA yielded a single band at greater than 10 kb, whereas the human DNA had the expected single band at 4.8kb. Analyses of these human-mouse cell hybrids demonstrated that the human alpha 1(type II) procollagen gene segregates with chromosome 12.

摘要

从39个人-鼠体细胞杂交系以及小鼠和人亲本细胞系中提取DNA。用EcoRI将DNA完全消化，并制备Southern印迹滤膜。这些滤膜在高严谨条件下与人类基因组亚克隆phHCol(II)A杂交，该亚克隆对应于人α1（II型）前胶原基因（COL2A1）。小鼠DNA在大于10 kb处产生一条带，而人类DNA在4.8 kb处出现预期的单一条带。对这些人-鼠细胞杂种的分析表明，人α1（II型）前胶原基因与12号染色体分离。

相似文献

1

Localization of human type II procollagen gene (COL2A1) to chromosome 12.

Somat Cell Mol Genet. 1984 Nov;10(6):651-5. doi: 10.1007/BF01535232.

2

Mapping of human autosomal phosphoglycerate kinase sequence to chromosome 19.

Somat Cell Mol Genet. 1986 Jul;12(4):395-401. doi: 10.1007/BF01570734.

3

Gene mapping of human ocular connective tissue proteins. Assignment of the structural gene for corneal type I procollagen to human chromosome 7 in human corneal stroma-mouse fibroblast somatic cell hybrids.

Invest Ophthalmol Vis Sci. 1981 Jul;21(1 Pt 1):73-9.

4

Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization.

Am J Hum Genet. 1982 May;34(3):381-7.

5

Regional chromosome mapping of human collagen genes alpha 2(I) and alpha 1(I) (COLIA2 and COLIA1).

Hum Genet. 1985;69(4):304-8. doi: 10.1007/BF00291646.

6

Human type I procollagen genes are located on different chromosomes.

Proc Natl Acad Sci U S A. 1982 Nov;79(21):6627-30. doi: 10.1073/pnas.79.21.6627.

7

The single copy gene coding for human alpha 1 (IV) procollagen is located at the terminal end of the long arm of chromosome 13.

Hum Genet. 1986 Oct;74(2):121-5. doi: 10.1007/BF00282074.

8

Further evidence for the dispersion of the human fibrillar collagen genes.

Am J Hum Genet. 1986 Jan;38(1):26-37.

9

Assignment of the genes for mouse type I procollagen to chromosome 16 using mouse fibroblast-Chinese hamster somatic cell hybrids.

Somatic Cell Genet. 1983 May;9(3):313-31. doi: 10.1007/BF01539141.

10

Localization of the human procollagen alpha 1(IV) gene to chromosome 13q34 by in situ hybridization.

Am J Hum Genet. 1986 Jan;38(1):38-44.

引用本文的文献

1

Analysis of three restriction fragment length polymorphisms in the human type II procollagen gene.

Am J Hum Genet. 1985 Jul;37(4):719-32.

2

A highly polymorphic region 3' to the human type II collagen gene.

Nucleic Acids Res. 1985 Jul 11;13(13):4613-22. doi: 10.1093/nar/13.13.4613.

3

Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2.

Proc Natl Acad Sci U S A. 1985 May;82(10):3385-9. doi: 10.1073/pnas.82.10.3385.

4

The single copy gene coding for human alpha 1 (IV) procollagen is located at the terminal end of the long arm of chromosome 13.

Hum Genet. 1986 Oct;74(2):121-5. doi: 10.1007/BF00282074.

5

The genes coding for human pro alpha 1(IV) collagen and pro alpha 2(IV) collagen are both located at the end of the long arm of chromosome 13.

Am J Hum Genet. 1988 Feb;42(2):309-14.

6

Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13.

Proc Natl Acad Sci U S A. 1987 Jan;84(2):512-6. doi: 10.1073/pnas.84.2.512.

7

Further evidence for the dispersion of the human fibrillar collagen genes.

Am J Hum Genet. 1986 Jan;38(1):26-37.

8

Nonrandom association of a type II procollagen genotype with achondroplasia.

Proc Natl Acad Sci U S A. 1985 Aug;82(16):5465-9. doi: 10.1073/pnas.82.16.5465.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。