Huerre-Jeanpierre C, Mattei M G, Weil D, Grzeschik K H, Chu M L, Sangiorgi F O, Sobel M E, Ramirez F, Junien C
Am J Hum Genet. 1986 Jan;38(1):26-37.
Recombinant DNA probes specific for the human pro alpha 1(II) and pro alpha 1(III) collagen chains have been used for the chromosomal localization of the two genes. Restriction endonuclease analysis of DNA from human-rodent hybrid cell lines in conjunction with in situ hybridization of human metaphasic chromosomes have shown that the gene coding for the pro alpha 1 chain of type II collagen (COL2A1) is located on chromosome 12 in the segment 12q131----12q132. Likewise, the gene coding for the pro alpha 1 chain of type III collagen (COL3A1) was assigned to the segment 2q31----2q323 of chromosome 2.
针对人原α1（II）和原α1（III）胶原链的重组DNA探针已用于这两个基因的染色体定位。对人-啮齿动物杂种细胞系DNA的限制性内切酶分析，结合人中期染色体的原位杂交，表明编码II型胶原原α1链（COL2A1）的基因位于12号染色体12q131----12q132区段。同样，编码III型胶原原α1链（COL3A1）的基因定位于2号染色体2q31----2q323区段。
