Svenberg T, Nilsson I, Samuelson K, Welbourn R D
Acta Chir Scand Suppl. 1984;520:59-61.
Emptying of the human gall-bladder has previously been shown to be associated with the release of motilin, both in the fasting state and after various stimuli, such as oral intake of fat or water. Whether motilin causes emptying of the human gall-bladder or whether the peptide is released by gall-bladder emptying is not presently known. Recent animal experiments suggest that intravenous infusion of pure porcine motilin causes emptying of the gall-bladder, both in the pig and the dog. In the present investigation, neither a physiological nor a pharmacological one-hour infusion of pure porcine motilin caused emptying of the human gall-bladder. In contrast, manual compression of the gall-bladder, at the beginning of operation for large bowel carcinoma, was followed by motilin release. The one-hour integrated motilin response after gall-bladder compression was about 10 times greater than in the control patients in whom the motilin response after palpation of the liver was similarly calculated. We conclude that flow of bile into the proximal small bowel is a signal for the release of motilin from the peptide-producing cells in the gut mucosa.
先前的研究表明，无论是在空腹状态下，还是在受到各种刺激（如口服脂肪或水）后，人体胆囊排空都与胃动素的释放有关。目前尚不清楚胃动素是否会导致人体胆囊排空，或者该肽是否由胆囊排空释放。最近的动物实验表明，静脉注射纯猪胃动素会导致猪和狗的胆囊排空。在本研究中，无论是生理剂量还是药理剂量的纯猪胃动素静脉输注1小时，均未导致人体胆囊排空。相反，在大肠癌手术开始时手动按压胆囊后，会出现胃动素释放。胆囊按压后1小时的胃动素综合反应比对照组患者大约10倍，对照组患者是通过触诊肝脏后以同样方式计算胃动素反应的。我们得出结论，胆汁流入近端小肠是肠道黏膜中产生该肽的细胞释放胃动素的信号。
