[利用白血病患儿外周血白细胞生产干扰素]

[Interferon production using the peripheral leukocytes of leukemic children].

作者信息

Nemirovskaia B M, Maiakova S A, Gavrilova I E, Zak E V, Makhonova L A

出版信息

Eksp Onkol. 1984;6(2):60-2.

Abstract

Interferon production by blood leucocytes was investigated in 26 children with various types of leukemia (acute lymphoblastic, acute myeloblastic and the blastic crisis of chronic myelocytic leukemia). The control group consisted of 6 children with lymphoadenopathy. Interferon synthesis was decreased in most cases of acute lymphoblastic leukemia. The persistent sharp reduction of interferon producing function of leucocytes is a factor of unfavourable prognosis in acute lymphoblastic leukemia of children, being associated with a more severe course of the disease, increased susceptibility to viral infection, and with a higher risk of relapse. In two cases of chronic myelocytic leukemia the level of interferon production was equal to or even higher than in the control group. It is supposed that the estimation of interferon production by leucocytes can be used as an additional factor in the differential diagnostics of obscure cases of children leukemia.

摘要

对26名患有各种类型白血病（急性淋巴细胞白血病、急性髓细胞白血病和慢性粒细胞白血病的原始细胞危象）的儿童进行了血液白细胞干扰素产生情况的研究。对照组由6名患有淋巴结病的儿童组成。在大多数急性淋巴细胞白血病病例中，干扰素合成减少。白细胞产生干扰素功能的持续急剧下降是儿童急性淋巴细胞白血病预后不良的一个因素，与疾病进程更严重、对病毒感染易感性增加以及复发风险更高有关。在两例慢性粒细胞白血病中，干扰素产生水平等于或甚至高于对照组。据推测，白细胞干扰素产生情况的评估可作为儿童白血病疑难病例鉴别诊断的一个附加因素。