Hankin J H, Kolonel L N, Hinds M W
J Natl Cancer Inst. 1984 Dec;73(6):1417-22.
A dietary history method for use in a case-control study of vitamin A and lung cancer is described. The method was designed to obtain estimates of the usual frequencies and quantities of 84 major food sources of vitamin A and carotene consumed prior to symptoms of disease in cases and during the same time period in matched controls. Amounts were estimated from photographs of each item that showed three different quantities. The development of the questionnaire is described in detail, as well as the data collection and analysis. The results of the study showed that relative to those men with the highest intakes, the men who consumed less vitamin A or carotene had a higher risk for lung cancer in a general dose-response fashion. These findings were not apparent for females. Recommendations regarding dietary methodology for future studies concerning vitamin A and carotene intakes include further research on the validation and reproducibility of the dietary methods, identification of appropriate biological markers that reflect past exposures of vitamin A and carotene, and further research on the vitamin A and carotene content of available food items.
本文描述了一种用于维生素A与肺癌病例对照研究的饮食史方法。该方法旨在获取病例在出现疾病症状之前以及匹配对照在同一时期内摄入的84种主要维生素A和胡萝卜素食物来源的通常频率和数量估计值。数量是根据显示三种不同数量的每种食物的照片来估计的。详细描述了问卷的编制过程以及数据收集和分析情况。研究结果表明，与摄入量最高的男性相比，摄入较少维生素A或胡萝卜素的男性患肺癌的风险总体呈剂量反应关系升高。这些发现对女性不明显。关于未来维生素A和胡萝卜素摄入量研究的饮食方法建议包括进一步研究饮食方法的有效性和可重复性，确定反映过去维生素A和胡萝卜素暴露情况的合适生物标志物，以及进一步研究现有食物中维生素A和胡萝卜素的含量。
