红白血病（K562）细胞含有一个功能性β-珠蛋白基因。
Erythroleukemia (K562) cells contain a functional beta-globin gene.
作者信息
Donovan-Peluso M, Young K, Dobkin C, Bank A
出版信息
Mol Cell Biol. 1984 Nov;4(11):2553-5. doi: 10.1128/mcb.4.11.2553-2555.1984.
Abstract
K562 cells are human erythroid cells that synthesize embryonic and fetal globins but not adult beta-globin. A cloned beta-globin gene was isolated from K562 cells and transfected into HeLa cells. The RNA transcripts produced were comparable in both amount and size to those obtained with a normal beta-globin gene.
摘要
K562细胞是人类红系细胞，可合成胚胎和胎儿珠蛋白，但不合成成人β珠蛋白。从K562细胞中分离出一个克隆的β珠蛋白基因，并将其转染到HeLa细胞中。产生的RNA转录本在数量和大小上与用正常β珠蛋白基因获得的转录本相当。
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