Gillespie J H
Proc Natl Acad Sci U S A. 1984 Dec;81(24):8009-13. doi: 10.1073/pnas.81.24.8009.
It is argued that the apparent constancy of the rate of molecular evolution may be an artifact due to the very slow rate of evolution of individual amino acids. A statistical analysis of protein evolution using a stationary point process as the null hypothesis leads to the conclusion that molecular evolution is episodic, with short bursts of rapid evolution followed by long periods of slow evolution. Such dynamics are incompatible with the neutral allele theory and require a revision of the standard interpretation of the molecular clock.
有人认为，分子进化速率看似恒定可能是一种假象，这是由于单个氨基酸的进化速率非常缓慢所致。以平稳点过程作为原假设对蛋白质进化进行统计分析后得出结论，分子进化是间歇性的，先是短时间的快速进化，随后是长时间的缓慢进化。这种动态与中性等位基因理论不相符，需要对分子钟的标准解释进行修正。
