Thomsen H S, Golman K, Svendsen O
Department of Diagnostic Radiology, Köbenhavns Amts Sygehus, Herlev, University of Copenhagen, Denmark.
Acta Radiol. 1991 Mar;32(2):182-3.
The potential tissue irritating effect of diatrizoate and iohexol was studied by injecting the contrast media into the right longissimus dorsi muscle of rabbits. The left muscle served as control. The animals were sacrificed 3 days after the injection, at which time muscle tissue was examined for macroscopic changes and loss of the muscle enzyme creatine kinase (CK) from the injection site was determined. An irregular area of necrotic muscle tissue and a hemorrhage was found at the injection site in rabbits given diatrizoate, whereas iohexol only caused hemorrhage. The local loss of CK activity following diatrizoate (0.64 g muscle tissue) was statistically significantly greater than following iohexol (0.18 g muscle tissue). It is concluded that this model seems to be useful for identification of the irritating potential of contrast media. It is also concluded that diatrizoate caused more damage to the local muscle tissue than iohexol.
通过将造影剂注入兔右侧背最长肌来研究泛影葡胺和碘海醇对组织的潜在刺激作用。左侧肌肉作为对照。注射后3天处死动物，此时检查肌肉组织的宏观变化，并测定注射部位肌肉酶肌酸激酶（CK）的流失情况。给予泛影葡胺的兔注射部位发现有不规则的坏死肌肉组织区域和出血，而碘海醇仅引起出血。泛影葡胺（0.64 g肌肉组织）注射后CK活性的局部损失在统计学上显著大于碘海醇（0.18 g肌肉组织）注射后。结论是该模型似乎有助于识别造影剂的刺激潜力。还得出结论，泛影葡胺对局部肌肉组织的损伤比碘海醇更大。
