[Effect of series E and F prostaglandins on the reaction of the pentosephosphate pathway of carbohydrate metabolism in isolated perfused rat organs].

The effects of prostaglandins E2 and F2 alpha on oxidative and non-oxidative reactions of the pentose phosphate pathway of carbohydrate metabolism in isolated perfused liver and uterus of the rat were studied. The prostaglandins (0.5 X 10(-8) M) activate dehydrogenase but do not practically affect the activity of non-oxidative enzymes of the pentose phosphate pathway. Upon perfusion of isolated rat liver and uterus by the prostaglandins, the degree of dehydrogenase activation depends on the perfusion time and the nature of the prostaglandins. Under effects of prostaglandin E2, the maximal activity of liver glucose-6-phosphate dehydrogenase (280% above the normal level) was observed already after 15 min, that of 6-phosphogluconate dehydrogenase (104% above the normal level) after 30 min. In the uterus, the maximal activity of these enzymes was induced by prostaglandin F2 alpha, showing an increase in the whole course of perfusion and after 1 hour exceeded the normal value by 120 and 80% for glucose-6-phosphate and 6-phosphogluconate dehydrogenases, respectively.