Abrahams J P, Nash D T, Gensini G G, Arno T
J Am Geriatr Soc. 1978 Jun;26(6):248-52. doi: 10.1111/j.1532-5415.1978.tb02397.x.
The relationship between age, biomedical risk factors and the progression of occlusive disease of the coronary arteries was studied in 176 patients (age range, 27-66 years) who had undergone at least two cine angiograms. The biomedical risk factors of interest were serum concentrations of cholesterol and triglycerides, smoking, hypertension, diabetes mellitus, family history of coronary disease, electrocardiographic abnormalities, obesity, and age. The findings did not reveal any significant differences in mean lipid levels between patients showing progression of disease and those who did not. However, the distribution of serum cholesterol values indicated more hypercholesterolemic patients among the disease-progression group, and more patients with ideal cholesterol levels among the no-progression group. The other biomedical variables did not appear to be related to the progression of coronary disease. Among the older patients, hypercholesterolemia and diabetes mellitus were related to disease progression. Among the younger patients, smoking was related to progression.
对176例（年龄范围27 - 66岁）至少接受过两次心血管造影的患者，研究了年龄、生物医学风险因素与冠状动脉闭塞性疾病进展之间的关系。所关注的生物医学风险因素包括血清胆固醇和甘油三酯浓度、吸烟、高血压、糖尿病、冠心病家族史、心电图异常、肥胖及年龄。研究结果未显示疾病进展患者与未进展患者之间的平均血脂水平有任何显著差异。然而，血清胆固醇值的分布表明，疾病进展组中高胆固醇血症患者更多，无进展组中胆固醇水平理想的患者更多。其他生物医学变量似乎与冠心病进展无关。在老年患者中，高胆固醇血症和糖尿病与疾病进展有关。在年轻患者中，吸烟与疾病进展有关。
