Allen L B, Hintz O J, Wolf S M, Huffman J H, Simon L N, Robins R K, Sidwell R W
J Infect Dis. 1976 Jun;133 Suppl:A178-83. doi: 10.1093/infdis/133.supplement_2.a178.
9-beta-D-Arabinofuranosylhypoxanthine 5'-monophosphate, administered orally or topically, increased the number of survivors and mean day of death in mice inoculated intravaginally with Herpesvirus hominis type 2. Topical application of the drug in ointment significantly reduced the severity of genital lesions. Orally administered drug did not appreciably reduce genital lesions, but it did cause significant increases in the number of survivors and mean day of death, even when administration was started as late as three days after inoculation of virus. Drug applied both topically and orally was more effective than drug applied by either route along. For topical application an ointment was found to be a better vehicle than polyvinyl alcohol or dimethysulfoxide. In some circumstances the vehicle of drug administration itself had some efficacy.
9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸，经口服或局部给药后，可增加经阴道接种人2型疱疹病毒的小鼠的存活数量并延长平均死亡天数。以软膏形式局部应用该药物可显著减轻生殖器病变的严重程度。口服该药物并未明显减轻生殖器病变，但确实使存活数量显著增加且平均死亡天数延长，即使在接种病毒三天后才开始给药亦是如此。局部和口服联合用药比单独采用任何一种给药途径更有效。对于局部应用而言，发现软膏作为载体比聚乙烯醇或二甲亚砜更好。在某些情况下，给药载体本身也具有一定疗效。
