抗原-抗体复合物介导的抑制中对抗体Fc部分的需求。
The requirement for the Fc portion of antibody in antigen-antibody complex-mediated suppression.
作者信息
Morgan E L, Tempelis C H
出版信息
J Immunol. 1978 May;120(5):1669-71.
PMID:659870
Abstract
The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab')2 fragments of pheasant anti-BSA, no suppression was observed, indicating that the Fc piece was indeed essential for the induction of Ag-Ab complex-mediated suppression.
摘要
在体内和体外研究了抗体Fc部分在免疫复合物诱导的抑制作用中的角色。发现抗原过量（Ag1Ab1）时形成的牛血清白蛋白（BSA）-雉鸡抗牛血清白蛋白复合物，既能抑制对牛血清白蛋白的反应，也能抑制对绵羊红细胞（SRBC）的反应。当用雉鸡抗牛血清白蛋白的F(ab')2片段形成复合物时，未观察到抑制作用，这表明Fc片段确实是诱导抗原-抗体复合物介导的抑制作用所必需的。
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