ICI 35 868在人体中的药代动力学评估。不同注射速率的单次诱导剂量。

Pharmacokinetic evaluation of ICI 35 868 in man. Single induction doses with different rates of injection.

作者信息

Adam H K, Briggs L P, Bahar M, Douglas E J, Dundee J W

出版信息

Br J Anaesth. 1983 Feb;55(2):97-103. doi: 10.1093/bja/55.2.97.

DOI:10.1093/bja/55.2.97

Abstract

Blood concentrations of ICI 35 868 have been measured in patients following a single bolus dose of 2 mg kg-1. Three different rates of injection of the anaesthetic agent (3-5s, 20s and 40 or 50s) were examined. Pharmacokinetic indices, derived from blood concentrations of ICI 35 868, were independent of the speed of injection. The blood profiles could be described by a two-compartment open model with a mean alpha-phase half-life of 2.5 min and a mean beta-phase half-life of 54.5 min. The mean total body clearance was 3454 ml min-1. Similar data were obtained from a 4-mg kg-1 dose. The mean recovery time (4.4 min) and concentration of ICI 35 868 at awakening (1.05 micrograms ml-1) were also independent of the rate of injection. Using the derived pharmacokinetic model, predictions of drug concentrations have been made for repeated bolus doses, or infusions, of ICI 35 868.

摘要

已对单次静脉注射2 mg·kg⁻¹剂量的ICI 35 868后的患者进行了血药浓度测定。研究了三种不同的麻醉剂注射速度（3 - 5秒、20秒和40或50秒）。由ICI 35 868血药浓度得出的药代动力学指标与注射速度无关。血药浓度曲线可用二室开放模型描述，平均α相半衰期为2.5分钟，平均β相半衰期为54.5分钟。平均总体清除率为3454 ml·min⁻¹。从4 mg·kg⁻¹剂量获得了类似的数据。平均恢复时间（4.4分钟）和苏醒时ICI 35 868的浓度（1.05 μg·ml⁻¹）也与注射速度无关。利用推导的药代动力学模型，已对ICI 35 868的重复静脉注射剂量或输注的药物浓度进行了预测。