ICI 35 868作为静脉诱导剂的初步经验：与阿耳忒辛的比较。

Preliminary experience with ICI 35 868 as an i.v. induction agent: comparison with althesin.

作者信息

Rogers K M, Dewar K M, McCubbin T D, Spence A A

出版信息

Br J Anaesth. 1980 Aug;52(8):807-10. doi: 10.1093/bja/52.8.807.

DOI:10.1093/bja/52.8.807

Abstract

In a small open dose-finding study the i.v. dose of ICI 35 868 required to induce anaesthesia in healthy adults was 2 mg kg-1. Comparison of this dose with Althesin 0.05 ml kg-1 for i.v. induction, both injected over 30 s suggests that they have similar effects on heart rate, arterial pressure and breathing. The mean times to loss of eyelash reflex were 57 +/- SD 10.1 s (ICI 35 868) and 46 +/- 3.9s (Althesin). The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin.

摘要

在一项小型开放剂量探索性研究中，健康成年人静脉注射ICI 35 868诱导麻醉所需的剂量为2毫克/千克。将该剂量与静脉注射诱导用的阿法沙龙0.05毫升/千克进行比较，二者均在30秒内注射完毕，结果表明它们对心率、动脉压和呼吸的影响相似。睫毛反射消失的平均时间分别为57±标准差10.1秒（ICI 35 868）和46±3.9秒（阿法沙龙）。10名患者中有7名在注射新药时出现疼痛和不适，但与阿法沙龙相比，新药引起的不自主运动较少。