Wright P J, Clarke R S, Dundee J W, Briggs L P, Greenfield A A
Br J Anaesth. 1984 Jun;56(6):613-6. doi: 10.1093/bja/56.6.613.
The infusion rate of propofol which would produce anaesthesia, when combined with nitrous oxide in oxygen, was studied in 75 fit unpremedicated patients undergoing body surface operations. The infusion rates were based on multiples of the median dose required to produce anaesthesia by intermittent injection in an additional 20 patients. The scatter of doses showed a right skew, for both intermittent and continuous use. This was corrected by loge transformation and derived data presented graphically.
在75例接受体表手术的健康、未用术前药的患者中，研究了丙泊酚与氧化亚氮-氧气混合使用时产生麻醉作用的输注速率。输注速率基于另外20例患者通过间歇注射产生麻醉所需中位剂量的倍数。无论是间歇使用还是持续使用，剂量分布均呈右偏态。通过自然对数转换对其进行校正，并以图形方式呈现推导数据。
