Watts M E, Hodgkiss R J, Jones N R, Sehmi D S, Woodcock M
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Mar;43(3):329-36. doi: 10.1080/09553008314550371.
A liquid flow rapid-mixing apparatus has been used to study the role of lipophilicity (octanol: water partition coefficient, P) in the sensitization of hypoxic V79 cells by nitroimidazoles. Sensitization by seven neutral 2-nitroimidazoles of similar reduction potential but widely differing partition (0.11-77) and one basic 2-nitroimidazole (pKa=8.9; p=8.5 (of free base)) was studied as a function of pre-irradiation contact time ca. 3-40 ms. With increasing P, sensitization occurs at increasingly shorter pre-irradiation contact times. The results suggest that even though factors other than passive diffusion control the sensitization observed with the base Ro 03-8799 it is able to diffuse to the target site faster than midonidazole.
一种液体流动快速混合装置已被用于研究亲脂性（正辛醇：水分配系数，P）在硝基咪唑对缺氧V79细胞致敏作用中的角色。研究了七种具有相似还原电位但分配系数差异很大（0.11 - 77）的中性2 - 硝基咪唑和一种碱性2 - 硝基咪唑（pKa = 8.9；p = 8.5（游离碱））的致敏作用与预辐照接触时间（约3 - 40毫秒）的关系。随着P的增加，致敏作用在越来越短的预辐照接触时间出现。结果表明，尽管除被动扩散之外的其他因素控制着碱性的Ro 03 - 8799所观察到的致敏作用，但它比米多硝唑能更快地扩散到靶位点。
