类风湿关节炎患者体内类风湿关节炎相关核抗原抗体及免疫复合物与疾病活动度的相关性
Correlation of antibody to rheumatoid arthritis associated nuclear antigen and immune complexes to disease activity in patients with rheumatoid arthritis.
作者信息
Alspaugh M A, Rosenstock D, Biundo J J, Gupta R C
出版信息
Clin Exp Immunol. 1983 Feb;51(2):278-84.
Twenty-seven patients with rheumatoid arthritis (RA) maintained on drug regimens were studied monthly for 6-10 months. Disease activity was assessed and levels of anti-RA associated nuclear antigen (RANA) and immune complexes were determined. Anti-RANA generally paralleled disease activity in 64% of cases. Immune complex levels paralleled disease activity in 56% of cases and paralleled anti-RANA in 52% of patients. Immune complexes paralleled anti-RANA together with disease activity in only 33% of patients. Anti-RANA and/or immune complex levels paralleled disease activity indices in 82% of cases. Significant fluctuations (greater than or equal to four-fold) in anti-RANA were frequently found (65%) and were associated with concordant changes in immune complex levels 50% of the time and with changes in disease activity indices 59% of the time. The data suggest that levels of anti-RANA and immune complexes may be important in RA and warrant further investigation.
对27名接受药物治疗方案的类风湿性关节炎（RA）患者进行了为期6至10个月的每月一次研究。评估疾病活动度，并测定抗RA相关核抗原（RANA）和免疫复合物水平。在64%的病例中，抗RANA水平通常与疾病活动度平行。免疫复合物水平在56%的病例中与疾病活动度平行，在52%的患者中与抗RANA平行。免疫复合物仅在33%的患者中与抗RANA以及疾病活动度同时平行。抗RANA和/或免疫复合物水平在82%的病例中与疾病活动指数平行。抗RANA的显著波动（大于或等于四倍）经常出现（65%），并且50%的时间与免疫复合物水平的一致变化相关，59%的时间与疾病活动指数的变化相关。数据表明，抗RANA和免疫复合物水平在类风湿性关节炎中可能很重要，值得进一步研究。
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