Gasparrini W G, Satz P, Heilman K, Coolidge F L
J Neurol Neurosurg Psychiatry. 1978 May;41(5):470-3. doi: 10.1136/jnnp.41.5.470.
Patients with left hemisphere disease have been noted to be depressed while those with right hemisphere disease appear indifferent. While patients with left hemisphere disease frequently have a greater cognitive deficit, patients with right hemisphere disease have difficulty in expressing affectively intoned speech. The Minnesota Multiphasic Personality Inventory (MMPI) can demonstrate underlying affective experience and is not dependent on affectively intoned speech. The purpose of this study was to determine whether a difference in affective moods, as assessed by the MMPI, was related to laterality of lesion in patients matched for severity of cognitive and motor dysfunction. Seven of the 16 subjects with left hemisphere dysfunction and none of the eight subjects with right hemisphere dysfunction showed an elevation on the depression scale. This observation not only confirms previous clinical observations but also demonstrates that these asymmetries cannot be ascribed completely to hemisphere-related differences in cognitive deficits or expressive abilities.
据观察，左半球病变的患者会出现抑郁情绪，而右半球病变的患者则表现出冷漠。虽然左半球病变的患者通常有更严重的认知缺陷，但右半球病变的患者在表达情感语调的言语方面存在困难。明尼苏达多相人格调查表（MMPI）可以揭示潜在的情感体验，且不依赖于情感语调的言语。本研究的目的是确定，在认知和运动功能障碍严重程度相匹配的患者中，通过MMPI评估的情感情绪差异是否与病变的侧别有关。16名左半球功能障碍的受试者中有7名，而8名右半球功能障碍的受试者中无人在抑郁量表上得分升高。这一观察结果不仅证实了先前的临床观察，还表明这些不对称性不能完全归因于与半球相关的认知缺陷或表达能力差异。
