Matias J R, Orentreich N
J Invest Dermatol. 1983 Jun;80(6):516-9. doi: 10.1111/1523-1747.ep12535112.
Subcutaneous injection of epidermal growth factor (EGF) into the pinna of adult female and castrated male Syrian hamsters resulted in an increase in the number of cells per sebaceous gland unit. The effect of EGF on the sebaceous cell number was localized to the treated ear and accompanied by epidermal hyperplasia. The injection of testosterone into the ear also produced an increase in the cell number. When testosterone and EGF were injected together, the two hormones exerted an additive effect on the sebaceous glands of female hamsters. This is the first demonstration of a sebotrophic action of this polypeptide hormone.
向成年雌性和去势雄性叙利亚仓鼠的耳廓皮下注射表皮生长因子（EGF），导致每个皮脂腺单位的细胞数量增加。EGF对皮脂腺细胞数量的影响局限于注射部位的耳朵，并伴有表皮增生。向耳朵注射睾酮也会使细胞数量增加。当睾酮和EGF一起注射时，这两种激素对雌性仓鼠的皮脂腺产生相加作用。这是首次证明这种多肽激素具有促皮脂分泌作用。
