来自正常供体的淋巴细胞在孕期可能已致敏，从而在体外产生针对人类次要组织相容性抗原的细胞毒性细胞。
In vitro generation of cytotoxic cells specific for human minor histocompatibility antigens by lymphocytes from a normal donor potentially primed during pregnancy.
作者信息
Tekolf W A, Shaw S
出版信息
J Exp Med. 1983 Jun 1;157(6):2172-7. doi: 10.1084/jem.157.6.2172.
Abstract
A normal female donor (H9) is described, whose cells generate strong cytotoxicity against a human minor histocompatibility antigen in vitro. These cytotoxic T lymphocytes are generated after secondary restimulation with cells from an HLA-A, -B, -C, and -DR-matched donor and are HLA restricted (HLA-B7). No other donor could be identified whose cells responded to this antigen. The two children of donor H9 are virtually HLA identical to her and one of the children expresses the relevant minor histocompatibility antigen. These data suggest that priming in vivo during pregnancy has facilitated cytotoxic T cell response to human minor histocompatibility antigens in vitro.
摘要
描述了一名正常女性供体（H9），其细胞在体外对一种人类次要组织相容性抗原产生强烈的细胞毒性。这些细胞毒性T淋巴细胞是在与一名HLA - A、- B、- C和 - DR匹配的供体的细胞进行二次再刺激后产生的，并且具有HLA限制性（HLA - B7）。未发现其他供体的细胞对该抗原有反应。供体H9的两个孩子实际上与她的HLA相同，其中一个孩子表达相关的次要组织相容性抗原。这些数据表明，孕期的体内致敏促进了体外对人类次要组织相容性抗原的细胞毒性T细胞反应。
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Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses.存在一系列新的B细胞抗原分离株的证据，这些抗原由HLA - D区域编码，并刺激二次同种异体增殖和细胞毒性反应。
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In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.小鼠对雄性特异性（H-Y）抗原的体外细胞介导免疫反应。
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Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.细胞毒性T细胞检测到的相互作用抗原，以主要组织相容性复合体作为修饰因子。
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Transplacental passage of blood cells.血细胞的胎盘转运。
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