抗自身人类白细胞抗原可能呈克隆性表达。
Anti-self HLA may be clonally expressed.
作者信息
Goulmy E, Hamilton J D, Bradley B A
出版信息
J Exp Med. 1979 Feb 1;149(2):545-50. doi: 10.1084/jem.149.2.545.
Abstract
A monolayer absorption technique was used to test the hypothesis that killer cells directed to self HLA-associated minor histocompatibility antigens (H-Y) were divisible into subsets. The results showed that sensitized killer cells, which recognized two combined antigens HLA-A2; H-Y and HLA-B7; H-Y could indeed be divided into two populations. One was directed to HLA-A2; H-Y and the other to HLA-B7; H-Y. These results can be interpreted in the context of the altered self hypothesis. However, when interpreted in the context of the dual recognition hypothesis, they strongly suggest that independant clones of killer T cells exist which are committed to the recognition of self HLA.
摘要
采用单层吸附技术来检验针对自身HLA相关的次要组织相容性抗原（H-Y）的杀伤细胞可分为不同亚群这一假说。结果显示，识别两种复合抗原HLA-A2；H-Y和HLA-B7；H-Y的致敏杀伤细胞确实可分为两个群体。一个群体针对HLA-A2；H-Y，另一个群体针对HLA-B7；H-Y。这些结果可以在自身改变假说的背景下进行解释。然而，当在双重识别假说的背景下进行解释时，它们强烈表明存在致力于识别自身HLA的独立杀伤性T细胞克隆。
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Human cell-mediated cytotoxicity against modified target cells is restricted by HLA.人类细胞介导的针对修饰靶细胞的细胞毒性受人类白细胞抗原（HLA）限制。
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