[Quantitative behavior of pregnancy-specific beta glycoproteins (Sp1) in the amniotic fluid in normal and pathologic pregnancies].

SP1 levels of 150 amniotic fluid samples from 70 healthy gravidae and 63 gravidae suffering from different disturbances of pregnancy obtained between gestational weeks 16 and 42 have been estimated by means of the simple radial immunodiffusion method. For this end amniotic fluid has been tenfold concentrated by lyophilisation. SP1 concentrations increase gradually during pregnancy, but individual differences are wide especially at the end of pregnancy. The regression line ascends. In the average, the SP1 concentration of amniotic fluid is 1 per cent of the serum values. Cases of rhesus isoimmunization and EPH-gestosis are often correlated with high amniotic fluid levels of SP1. However, the diagnostic importance is restricted by a considerable overlap of the confidence intervals. The significance of amniotic fluid SP1 as an additional parameter for risk pregnancies is, nevertheless, to be discussed.