Straube W, Jahns E, Leisner J, Briese V
Zentralbl Gynakol. 1983;105(5):270-8.
SP1 levels of 150 amniotic fluid samples from 70 healthy gravidae and 63 gravidae suffering from different disturbances of pregnancy obtained between gestational weeks 16 and 42 have been estimated by means of the simple radial immunodiffusion method. For this end amniotic fluid has been tenfold concentrated by lyophilisation. SP1 concentrations increase gradually during pregnancy, but individual differences are wide especially at the end of pregnancy. The regression line ascends. In the average, the SP1 concentration of amniotic fluid is 1 per cent of the serum values. Cases of rhesus isoimmunization and EPH-gestosis are often correlated with high amniotic fluid levels of SP1. However, the diagnostic importance is restricted by a considerable overlap of the confidence intervals. The significance of amniotic fluid SP1 as an additional parameter for risk pregnancies is, nevertheless, to be discussed.
采用简单的放射免疫扩散法对70例健康孕妇和63例患有不同妊娠并发症的孕妇在妊娠16至42周期间获取的150份羊水样本中的SP1水平进行了评估。为此，通过冻干将羊水浓缩了10倍。SP1浓度在孕期逐渐升高，但个体差异很大，尤其是在妊娠末期。回归线上升。平均而言，羊水的SP1浓度为血清值的1%。恒河猴血型免疫和妊娠高血压综合征病例常与羊水中高SP1水平相关。然而，诊断重要性受到置信区间相当大的重叠的限制。尽管如此，羊水SP1作为高危妊娠的一个附加参数的意义仍有待讨论。
