Maeda H, Juji T, Mitsui H, Sonozaki H, Okitsu K
Ann Rheum Dis. 1981 Jun;40(3):299-302. doi: 10.1136/ard.40.3.299.
Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with 46.1% in normal controls (P less than 0.001). However, a sex difference in the frequency of HLA DR4 in patients was noted. HLA DR4 was found in 80.6% of male patients, which was highly significant compared with controls (P less than 0.0005), while only a borderline increase of 60.5% was found in female patients (P less than 0.05). In addition, the frequency of HLA DR2 was remarkably low in male patients. These suggest the possible heterogeneity of rheumatoid arthritis in Japanese.
对88名日本类风湿性关节炎患者和104名正常日本人进行了HLA A、B、C和DR抗原分型。患者中HLA DR4的频率为70.5%，而正常对照组为46.1%（P<0.001）。然而，在患者中发现HLA DR4频率存在性别差异。80.6%的男性患者存在HLA DR4，与对照组相比差异极为显著（P<0.0005），而女性患者中仅略有增加，为60.5%（P<0.05）。此外，男性患者中HLA DR2的频率显著较低。这些表明日本类风湿性关节炎可能存在异质性。
