Adler L T, LeBeau M M, Adler F L
Transplantation. 1983 Jun;35(6):530-4. doi: 10.1097/00007890-198306000-00003.
Transfer of adult spleen, lymph node, or bone marrow cells to newborn recipients matched with the donor with respect to the major histocompatibility antigen or antigens, but mismatched with regard to immunoglobulin allotypes results in lasting B cell chimerism. Using such chimeras as donors for secondary recipients, the persistence of B cells from the original donor and the ability of such cells to propagate in the secondary recipient have been demonstrated. In contrast to the effective establishment of donor B cells in primary and secondary recipients, functional T cells of donor origin were not demonstrable among lymphocytes of primary recipients.
将成年供体的脾脏、淋巴结或骨髓细胞移植到与供体在主要组织相容性抗原方面相匹配，但在免疫球蛋白同种异型方面不匹配的新生受体中，会导致持久的B细胞嵌合现象。以这些嵌合体作为二级受体的供体，已证明来自原始供体的B细胞能够持续存在，并能在二级受体中增殖。与供体B细胞在一级和二级受体中有效建立形成对比的是，在一级受体的淋巴细胞中未检测到供体来源的功能性T细胞。
